Mission Our Story Technology Approach API Contact

GETTING TIME BACK

Accelerating precision medicine through advanced targeting technology

Our Mission

We enable targeted medicine delivery and addressing the precise cause of disease at its root, making a new generation of medicine possible.

At Ligandal, we believe time is the most precious resource. Our platform gives that back to patients, researchers, and healthcare providers through targeted therapeutic delivery approaches that target the locations of disease.

Our Vision

A world where disease is no longer a limitation to human potential, where precision medicine gives people back the time to live the lives they choose.

Our Mission

To solve delivery - the final frontier of medicine. We make medicine precise, personalized, and predictive. We enable cures and make diagnostic-responsive medicine the paradigm.

Our Promise

To transform medicine through breakthrough, enabling technology that enhances targeting specificity, selectivity, and cellular internalization 10x beyond current standards.

10x
Research Time Saved

Our Story

Andre Watson, Founder

A Mission Born from Scientific Vision

Ligandal was founded on a simple yet powerful principle: everyone deserves more time. Andre Watson, our founder and CEO, established Ligandal with a vision for precision medicine targeting that allows for diseases to be approached at their molecular roots, with the aim of improving patient outcomes through accelerated translation of insights into cures.

Witnessing firsthand how years are lost to ineffective treatments and trial-and-error approaches, we set out to create technology that would fundamentally change how diseases are targeted and treated.

Today, our PDC (Peptide Direct Conjugate) technology, driven by LigandAI® and Predictive Interactomics®, represents the culmination of over 10 years of R&D directed towards that vision—precision medicine that targets disease at its molecular roots with unprecedented accuracy and efficiency.

"We're not just developing treatments; we're giving time back to people. Time for research breakthroughs. Time for patients to live their lives beyond their disease. Time that matters."

Our Technology

Targeted Technology

Targeted

Accurate delivery to specific disease target markers, minimizing off-target effects.

Precise Technology

Precise

Engineered at the molecular level for exact interaction with the precise locations of disease.

Delivery Technology

Delivered

Enabling advanced delivery systems to ensure therapeutics reach their intended targets.

Targeted & Precise: Ligandal's core technology platform enables precise targeting of the molecular causes of disease, delivering therapeutics with unparalleled accuracy, and ultimately giving time back to patients. Our PDC technology reaches disease targets with atomic precision.

Predictive & Preventative: Founded on over a decade of nanotech and bioengineering R&D, our approach combines cutting-edge computational design, advanced molecular engineering, and innovative delivery systems to create next-generation delivery of therapeutic solutions that can predict and prevent disease progression.

Precision & Delivered: Our platform integrates the latest advancements in Predictive Interactomics®, analytics, and disease intelligence to create a foundational programmatic matter layer for engineered biology. This convergence of molecular engineering and computational intelligence allows us to decode complex biological systems and design targeted interventions with unprecedented precision.

Using LigandAI®, our platform provides hands-on predictive intelligence about diseases, biomarkers, and generative ligands tailored to your specific needs, empowering more effective and personalized therapeutic development. This unified approach enables truly preventative, personalized, and predictive medicine.

Receptor Targeting Technology

Receptor Targeting Technology

Our PDC technology targets specific receptors with atomic precision. Using custom-designed peptides with optimized binding properties, we deliver therapeutic payloads directly to cells in the precise physiological locations of disease.

How Receptor Targeting Works

  • Specificity: Our peptides are designed to bind only to specific receptors in the exact locations where treatment is needed
  • Affinity: Modular and predictive binding affinity ensures enhanced targeting precision
  • Selectivity: Minimal binding to off-target receptors reduces side effects
  • Customization: Our platform can target virtually any receptor with custom-designed peptides

Using computational design and screening, we identify peptide sequences that bind targets with unprecedented precision. This approach enables targeting of previously "undruggable" disease pathways.

Cellular Delivery Process

Cellular Delivery Process

Our PDC technology targets specific receptors on cell surfaces in the precise physiological locations of disease. The peptide-directed particles enter cells through receptor-mediated endocytosis, delivering therapeutic payloads to their intended targets. This approach improves efficacy while reducing off-target effects.

Delivery Process Steps

  1. Targeting: PDCs bind specifically to receptors in the precise locations where treatment is needed
  2. Internalization: Receptor-mediated endocytosis draws PDCs into the cell
  3. Endosomal Escape: Specialized mechanisms release the therapeutic payload into the cytoplasm or nucleus
  4. Therapeutic Action: Payloads reach their intracellular targets for maximum efficacy

This multi-step process ensures therapeutics not only reach the right cells but also maintain their activity once inside. Our technology is payload-agnostic and can deliver mRNA, DNA, CRISPR, and other gene editing technologies.

PDC Technology Key Benefits

Our peptide-directed conjugate (PDC) technology delivers therapeutic payloads with precision and efficiency.

Precise Targeting

PDC peptides recognize and bind to specific cellular receptors with high affinity and selectivity, ensuring targeted delivery to disease sites.

Efficient Internalization

Once bound, PDCs trigger receptor-mediated endocytosis for efficient cellular internalization, enhancing therapeutic delivery.

Payload Flexibility

Our technology is payload-agnostic, compatible with mRNA, DNA, CRISPR, and other gene editing technologies for versatile therapeutic applications.

The Time Impact of Precision Medicine

NOW

10x
Research Time Saved

Faster development with our custom targeting methodologies and Predictive Interactomics®

FUTURE

95%
Undrugged Precision Targets Accessible

Enabling life-saving cures for previously unreachable disease targets

Our technology gives time back to researchers, companies, and ultimately patients by addressing root causes of disease with precision, leading to years of quality life gained instead of just managing symptoms.

Our Approach

Identify

Precise identification of disease mechanisms at the molecular level.

Design

Custom design of targeting therapeutics with computational precision.

Deliver

Advanced delivery systems ensure therapeutics reach their intended targets.

Transform

Reshaping treatment paradigms with curative potential.

API & Integration

API ACCESS

CLOSED BETA

API access is available as a closed beta. Contact us for access requests and to be notified of general availability.

Predictive Interactomics®

Access our powerful platform for peptide design, binding affinity prediction, and target analysis.

Developer Resources

Comprehensive documentation, code examples, and SDKs for seamless integration.

Request Beta Access

YOUR MOLECULES. YOUR LNPs. TARGETED THE LIGANDAL WAY.

CUSTOM CONJUGATES

Revolutionize Your Delivery Systems with Precision-Targeted LNP Conjugates

Unlock unprecedented targeting capabilities for your therapeutic molecules. Our revolutionary platform combines your lipid nanoparticles (LNPs) with our precision peptide delivery systems, creating highly targeted conjugates that dramatically enhance delivery efficiency and specificity.

Your Molecules

Integrate your therapeutic payloads—whether nucleic acids, small molecules, or biologics—into our customized delivery systems without compromising their stability or activity.

Your LNPs

We enhance your existing LNP formulations with our proprietary targeting peptides, dramatically improving their specificity and cellular uptake where it matters most.

Targeted Precision

Direct delivery to specific tissues and cell types with atomic precision, minimizing off-target effects and maximizing therapeutic efficacy at lower doses.

LNP conjugates available upon request — Elevate your research with precision that matters.

Schedule a Consultation

Redefine What's Possible With Your Therapeutics

UP TO 25×

Increased Delivery Efficiency

90%+

Targeted Specificity

UP TO 5×

Lower Effective Dose

ONE-CLICK PEPTIDE DESIGN PLATFORM

COMING SOON

Design custom peptides and have them delivered to your lab within weeks

Our one-click peptide design and delivery platform is in final development. Sign up now to be first in line when we launch. Seamlessly design, optimize, and order peptides tailored to your specific research needs.

Predictive Design

AI-powered peptide design algorithms that consider binding affinity, stability, and solubility

Rapid Turnaround

From in silico design to synthesized peptides in your lab within weeks

Quality Assured

Stringent quality controls for purity, accuracy, and structural integrity

Get Notified When We Launch

Sign up to be notified when our one-click peptide design platform becomes available.

We'll notify you as soon as our platform is ready for launch.

Contact Us

Interested in learning more about our technology or partnership opportunities?

📧

Get in Touch

Location: Long Island City, New York

contact@ligandal.com